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alkylating antineoplastics การใช้

ประโยคมือถือ
  • Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents.
  • The following nitrogen mustard ester of estradiol is an alkylating antineoplastic agent and has been marketed:
  • "' Estramustine "'( synthetic steroidal estrogen and alkylating antineoplastic agent that was never marketed.
  • Alkylating antineoplastic agents, for example, cause DNA damage, which is more harmful to cancer cells than regular cells.
  • LS-1727 is a nitrogen mustard ester of nandrolone that was developed as an alkylating antineoplastic agent but was never marketed.
  • Testifenon ( chlorphenacyl DHT ester ) is a nitrogen mustard ester of DHT that was developed as an alkylating antineoplastic agent but was never marketed.
  • Estramustine phosphate is also an estradiol ester, but with a nitrogen mustard moiety attached, and is used as an alkylating antineoplastic agent in the treatment of prostate cancer.
  • Platinum-based antineoplastic agents are sometimes described as " alkylating-like " due to similar effects as alkylating antineoplastic agents, although they do not have an alkyl group.
  • In addition, cytotoxic drugs, such as alkylating antineoplastic agents, used in treatment of cancer, work by inhibiting the proliferation of dividing cells, with the malignant cells as the desired target.
  • To see " how " ready, consider the Air raid on Bari, not an uninteresting article, especially as this bombing was the origin of perhaps the most widespread class of chemotherapy drugs, alkylating antineoplastic agents.
  • :Based on our Cyclophosphamide article, I would say that the PT group is " nitrogen mustard alkylating agent ", and the PD group is alkylating antineoplastic agent . talk ) 23 : 27, 24 May 2014 ( UTC)
  • "' Cytestrol acetate "'is a steroidal antiestrogen and an alkylating antineoplastic agent ( i . e ., moiety has been attached as an ester at the C3 position and acetate esters have been attached at the C11? and C17? positions.
  • For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard alkylating antineoplastic agents . although estramustine phosphate has been approved for and is used ( almost exclusively ) in the treatment of prostate cancer.
  • Electrophilic, soluble alkylating agents are often very toxic, due to their ability to alkylate DNA . They should be handled with proper PPE . This mechanism of toxicity is also responsible for the ability of some alkylating agents to perform as anti-cancer drugs in the form of alkylating antineoplastic agents, and also as chemical weapons such as mustard gas.
  • "' Estromustine "'( developmental code name "'Leo 271 f "'), also known as "'estrone 17?-3-N-bis ( 2-chloroethyl ) carbamate "'or "'estrone-cytostatic complex "', is a major active metabolite of the cystotatic estrogen and nitrogen mustard alkylating antineoplastic agent estramustine phosphate, a drug used in the treatment of prostate cancer.