alkylating antineoplastics การใช้
- Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents.
- The following nitrogen mustard ester of estradiol is an alkylating antineoplastic agent and has been marketed:
- "' Estramustine "'( synthetic steroidal estrogen and alkylating antineoplastic agent that was never marketed.
- Alkylating antineoplastic agents, for example, cause DNA damage, which is more harmful to cancer cells than regular cells.
- LS-1727 is a nitrogen mustard ester of nandrolone that was developed as an alkylating antineoplastic agent but was never marketed.
- Testifenon ( chlorphenacyl DHT ester ) is a nitrogen mustard ester of DHT that was developed as an alkylating antineoplastic agent but was never marketed.
- Estramustine phosphate is also an estradiol ester, but with a nitrogen mustard moiety attached, and is used as an alkylating antineoplastic agent in the treatment of prostate cancer.
- Platinum-based antineoplastic agents are sometimes described as " alkylating-like " due to similar effects as alkylating antineoplastic agents, although they do not have an alkyl group.
- In addition, cytotoxic drugs, such as alkylating antineoplastic agents, used in treatment of cancer, work by inhibiting the proliferation of dividing cells, with the malignant cells as the desired target.
- To see " how " ready, consider the Air raid on Bari, not an uninteresting article, especially as this bombing was the origin of perhaps the most widespread class of chemotherapy drugs, alkylating antineoplastic agents.
- :Based on our Cyclophosphamide article, I would say that the PT group is " nitrogen mustard alkylating agent ", and the PD group is alkylating antineoplastic agent . talk ) 23 : 27, 24 May 2014 ( UTC)
- "' Cytestrol acetate "'is a steroidal antiestrogen and an alkylating antineoplastic agent ( i . e ., moiety has been attached as an ester at the C3 position and acetate esters have been attached at the C11? and C17? positions.
- For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard alkylating antineoplastic agents . although estramustine phosphate has been approved for and is used ( almost exclusively ) in the treatment of prostate cancer.
- Electrophilic, soluble alkylating agents are often very toxic, due to their ability to alkylate DNA . They should be handled with proper PPE . This mechanism of toxicity is also responsible for the ability of some alkylating agents to perform as anti-cancer drugs in the form of alkylating antineoplastic agents, and also as chemical weapons such as mustard gas.
- "' Estromustine "'( developmental code name "'Leo 271 f "'), also known as "'estrone 17?-3-N-bis ( 2-chloroethyl ) carbamate "'or "'estrone-cytostatic complex "', is a major active metabolite of the cystotatic estrogen and nitrogen mustard alkylating antineoplastic agent estramustine phosphate, a drug used in the treatment of prostate cancer.